Destroy All Humans! 2 co-op

Split-screen for 2 players

2006 · Pandemic Studios · 75/100

Split-screen

Yes

PS2

Local

2 players

Online

Not documented

Cross-play

Not confirmed

Co-op at a glance

Split-screen: Yes
Local co-op: 2 players
Online co-op: Not documented
Full campaign in co-op: Not documented
Cross-play: Not documented
Platforms: Xbox, PlayStation 4, PlayStation 2
Developer: Pandemic Studios

Co-op details come from the IGDB games database. Missing entries mean “not documented”, not necessarily “not available”. Data checked: 2026-10-07

What it is

Assume the role of the human-hating alien Crypto once again, in the sci-fi action-adventure spoof, bound to enslave mankind. Take revenge on humanity for destroying your mothership. “Make War, not Love” and take on new enemies such as secret agents, giant creatures, Soviet Forces and even ninja warriors in an expanded open-world.

Frequently asked

Does Destroy All Humans! 2 have split screen?

Yes. Destroy All Humans! 2 has split screen on PS2, locally for 2 players.

How many players can play Destroy All Humans! 2 locally and online?

Locally: 2 players. Online: not documented.

Does Destroy All Humans! 2 support cross-play?

No cross-play is confirmed for Destroy All Humans! 2. Our cross-play data comes from a hand-maintained list, because the games database has no field for it.